Conditions
You don't have to be exact, but there should be certain conditions for your guinea pig to ensure safety. First, do not have your cage in direct sunlight. This means not putting your cage right by a window. The temperature should be between 60-85 degrees Farenheit.
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Guinea pigs are social and will grow depressed if they are alone, so you need to house two or more guyinea pigs together - not less than that.
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Housing Size
Since guinea pigs are larger rodents and multiple of them will be living together, they need a good deal of space. Two guinea pigs need at least 7.5 square feet of space, but more is always better. Also, the more guinea pigs, the bigger the space will need to be.
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Cage Types
There are not many, if any, wire cages that are big enough to house guinea pigs, despite being marketed towards them. The best type of cage for guinea pigs is storage grids.
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The grids should be at least 9 by 9 inches and the wires should be 1 or less inches apart. The space should be measured and checked to be big enough.
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Flooring of Cage
Guinea pigs do not need bedding as they do not burrow, but you should put a bottom to your guinea pigs' enclosure for ease and cleanliness. Something non-absorbent is best so pee will not simply sink through and can instead be wiped up. A (or multiple) water resistant table cloths are suitable and fairly cheap (depending on where you buy it).
Cleaning
With a water resistant mat, poop can be swept up and pee can be cleaned up easily. Just spot clean every day or so and you will be fine - this should not be too hard as you can do it before/after you interact with your guinea pig, a time you have already set aside to be with them.
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Cage Decoration
Food and Water Containers
You can get a water bottle with a stand or attach it to the wall of the enclosure for your guinea pigs' water source. You can also get a water bowl instead but you need to make sure you clean it out if poop or pee ever gets in it. Since the cage is fairly large and there are multiple guinea pigs, you may want to get multiple sources of water. This could be multiple bottles,. multiple cups, or a mix - whatever you and your guinea pigs prefer!
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Hide Houses
As prey animals, guinea pigs need lots of hide houses to take shelter in when they are scared. There should eb many to choose from around the cage and there should be some different types of hides (like tunnels or houses, made of hay, wood, ceramic, or something else).
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Chew Toys
As rodents, guinea pigs' teeth never stop growing and need lots of chews to shave the teeth down. There needs to be many chews so your guinea pig has variety and will be enriched by it. You can get different shaped chews, different flavors, different materials, etc. You can also make chews more enriching by putting food in the center of a ball chew that your guinea pig will try to get out.
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Other Enrichment Objects
Add things like rocks and logs to add different objects and textures to the cage to enrich your guinea pigs. You can make r buy food puzzles in which your guinea pigs have to move around things/work to get food in the object for some more enrichment. You can also have low hurdles or other toys to keep your guinea pigs' lives interesting.